Postdoctoral Research Fellowship in Chromatin Biology and Cancer Epigenetics
Job description
A four-year Postdoctoral Fellowship is available in the field of Chromatin and Epigenetics based at the Section of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, Norway.
Sarcomas are a heterogenous group of mesenchymal soft tissue and bone cancers comprising 1% of adult malignancies. The emerging knowledge is that a combination of genetic and epigenetic events can drive the onset and progression of tumours. Changes in epigenetic modifications and protein associations are very influential in regulation of chromatin structure and thereby gene expression. However, the understanding of which epigenetic events that are responsible for driving and sustaining Sarcomas are incomplete. We aim to identify Sarcoma weaknesses by mapping epigenetic aberrations that enable identification of novel cancer targets. This project funded by the Norwegian Cancer Society focuses on the mechanisms underlying chromatin interactions and gene deregulation in Sarcoma. To elucidate these mechanisms in Sarcoma the candidate will use genetic, pharmacological, biochemical, and genome-wide approaches such as immunohistochemistry, Chromatin Immunoprecipitation (ChIP-Seq), gene knockdown, immunoprecipitation, CRISPR-Cas9, drug screens, Fluorescence In Situ Hybridization and confocal and live-cell imaging.
We are looking for a highly competent candidate with strong experimental background in molecular biology and/or epigenetics that can work independently. The candidate should be able to collaborate in a research team of national and international researchers. The successful candidate should have hands-on experience with a broad range of methods in molecular biology, cell biology, and biochemistry that may include mammalian tissue culture, immunoprecipitation and confocal microscopy. Experience with cancer organoid models and/or bioinformatics is an advantage. We offer broad training possibilities in the required experimental methods within a stimulating academic environment in Centre for Cancer Cell Reprogramming (CanCell) and Institute of Basic Medical Sciences.
More about the position
The fellowship will be for a period of up to 4 years with no compulsory work. Starting date is from 15.05.24 and no later than 01.06.2024.
The main purpose of the fellowship is to qualify researchers for work in higher academic positions within their disciplines.
Qualification requirements
- Applicants must hold a degree equivalent to a Norwegian doctoral degree in Biochemistry, Molecular Biology or Cell Biology. Doctoral dissertation must be submitted for evaluation by the closing date. Appointment is dependent on the public defense of the doctoral thesis being approved.
- Fluent oral and written communication skills in English.
- Applicant are expected to be in the upper segment of their class with respect to academic credentials.
- The main purpose of postdoctoral research fellowships is to qualify researchers for work in top academic positions within their disciplines.
We offer
- Salary NOK 575 400 – 657 300 per annum depending on qualifications in position as Postdoctoral Research Fellow (position code 1352).
- A professionally stimulating working environment.
- Attractive welfare benefits and a generous pension agreement, in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activities.
- Opportunity to gain experience in teaching and supervision of students.
How to apply
The application must include
- Cover letter (statement of motivation, summarizing scientific work and research interest)
- A brief account (one page, as a separate file) of the applicant's research interests and motivation for applying for the position.
- CV (summarizing education, positions, pedagogical experience, administrative experience, and other qualifying activity).
- Copies of educational certificates (academic transcripts only with English translation if in other language).
- Copies of letters of recommendation.
- A complete list of publications.
- Description of up to 5 academic works that the applicant wishes to be considered by the evaluation committee.
- List of reference persons: 2-3 references (name, relation to candidate, e-mail, and phone number).
The application with attachments must be delivered in our electronic recruiting system. International applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English (or a Scandinavian language).
In assessing the applications, special emphasis will be placed on the documented, academic qualifications, the project description (whenever this is required in the call for applicants), and the quality of the project as well as the candidates motivation and personal suitability. Interviews with the best qualified candidates will be arranged.
It is expected that the successful candidate will be able to complete the project in the course of the period of employment.
Formal regulations
Please see the guidelines and regulations for appointments to Postdoctoral fellowships at the University of Oslo.
No one can be appointed for more than one Postdoctoral Fellow period at the University of Oslo.
According to the Norwegian Freedom of Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.
Inclusion and diversity are a strength. The University of Oslo has a personnel policy objective of achieving a balanced gender composition. Furthermore, we want employees with diverse professional expertise, life experience and perspectives.
If there are qualified applicants with disabilities, employment gaps or immigrant background, we will invite at least one applicant from each of these categories to an interview.
Contact information
For further information please contact: Ragnhild Eskeland, phone: +47 22 85 14 57, e-mail: [email protected] www.chromatome.no/www.cancell.no